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3odx

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[[Image:3odx.jpg|left|200px]]
 
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==Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF==
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The line below this paragraph, containing "STRUCTURE_3odx", creates the "Structure Box" on the page.
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<StructureSection load='3odx' size='340' side='right'caption='[[3odx]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3odx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odx OCA], [https://pdbe.org/3odx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odx RCSB], [https://www.ebi.ac.uk/pdbsum/3odx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odx ProSAT]</span></td></tr>
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{{STRUCTURE_3odx| PDB=3odx | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
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===Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF===
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==See Also==
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*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3odx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODX OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Z.]]
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[[Category: Large Structures]]
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[[Category: Guo, L.]]
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[[Category: Chen Z]]
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[[Category: Sprang, S R.]]
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[[Category: Guo L]]
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[[Category: Sternweis, P C.]]
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[[Category: Sprang SR]]
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[[Category: Sternweis PC]]

Current revision

Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF

PDB ID 3odx

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