2l85

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2l85" [edit=sysop:move=sysop])
Current revision (06:54, 1 May 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 2l85 is ON HOLD
+
==Solution NMR structures of CBP bromodomain with small molecule of HBS==
 +
<StructureSection load='2l85' size='340' side='right'caption='[[2l85]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2l85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L85 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L85:4-[(E)-(4-HYDROXYPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>L85</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l85 OCA], [https://pdbe.org/2l85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l85 RCSB], [https://www.ebi.ac.uk/pdbsum/2l85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l85 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
-
Authors: BORAH, J.C., MUJTABA, S., KARAKIKES, I., ZENG, L., MULLER, M., PATEL, J., MOSHKINA, N., MOROHASHI, K., ZHANG, W., GERONA-NAVARRO, G., HAJJAR, R.J., ZHOU, M.
+
==See Also==
-
 
+
*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
-
Description: Solution NMR structures of CBP bromodomain with small molecule of HBS
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Borah JC]]
 +
[[Category: Gerona-Navarro G]]
 +
[[Category: Hajjar RJ]]
 +
[[Category: Karakikes I]]
 +
[[Category: Morohashi K]]
 +
[[Category: Moshkina N]]
 +
[[Category: Mujtaba S]]
 +
[[Category: Muller M]]
 +
[[Category: Patel J]]
 +
[[Category: Zeng L]]
 +
[[Category: Zhang W]]
 +
[[Category: Zhou M]]

Current revision

Solution NMR structures of CBP bromodomain with small molecule of HBS

PDB ID 2l85

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l85"
Personal tools