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3pq1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Crystal structure of human mitochondrial poly(A) polymerase (PAPD1)== |
| + | <StructureSection load='3pq1' size='340' side='right'caption='[[3pq1]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3pq1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PQ1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pq1 OCA], [https://pdbe.org/3pq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pq1 RCSB], [https://www.ebi.ac.uk/pdbsum/3pq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pq1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/PAPD1_HUMAN PAPD1_HUMAN] Autosomal recessive spastic ataxia - optic atrophy - dysarthria. The disease is caused by mutations affecting the gene represented in this entry. MTPAP mutations result in a defect of mitochondrial mRNA maturation. Affected individuals exhibit a drastic decrease in poly(A) tail length of mitochondrial mRNA transcripts, including COX1 and RNA14 (PubMed:20970105).<ref>PMID:20970105</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAPD1_HUMAN PAPD1_HUMAN] Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.<ref>PMID:15547249</ref> <ref>PMID:15769737</ref> <ref>PMID:18172165</ref> <ref>PMID:20970105</ref> <ref>PMID:21292163</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Poly(A) RNA polymerase|Poly(A) RNA polymerase]] | |
| - | + | *[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]] | |
| + | *[[RNA uridylyltransferase|RNA uridylyltransferase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bai Y]] | ||
| + | [[Category: Chang JH]] | ||
| + | [[Category: Srivastava SK]] | ||
| + | [[Category: Tong L]] | ||
Current revision
Crystal structure of human mitochondrial poly(A) polymerase (PAPD1)
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