3q7b
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3q7b is ON HOLD Authors: Hastie, K.M., Kimberlin, C.R., Zandonatti, M.A., MacRae, I.J., Saphire, E.O. Description: Exonuclease domain of Lassa viru...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Exonuclease domain of Lassa virus nucleoprotein== | |
| + | <StructureSection load='3q7b' size='340' side='right'caption='[[3q7b]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3q7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7B FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7b OCA], [https://pdbe.org/3q7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7b RCSB], [https://www.ebi.ac.uk/pdbsum/3q7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lassa virus Josiah]] | ||
| + | [[Category: Hastie KM]] | ||
| + | [[Category: Kimberlin CR]] | ||
| + | [[Category: MacRae IJ]] | ||
| + | [[Category: Saphire EO]] | ||
| + | [[Category: Zandonatti MA]] | ||
Current revision
Exonuclease domain of Lassa virus nucleoprotein
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