3q7c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3q7c is ON HOLD Authors: Hastie, K.M., Kimberlin, C.R., Zandonatti, M.A., MacRae, I.J., Ollmann, E.O. Description: Exonuclease domain of Lassa viru...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Exonuclease domain of Lassa virus nucleoprotein bound to manganese== | |
| + | <StructureSection load='3q7c' size='340' side='right'caption='[[3q7c]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3q7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7c OCA], [https://pdbe.org/3q7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7c RCSB], [https://www.ebi.ac.uk/pdbsum/3q7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lassa virus Josiah]] | ||
| + | [[Category: Hastie KM]] | ||
| + | [[Category: Kimberlin CR]] | ||
| + | [[Category: MacRae IJ]] | ||
| + | [[Category: Saphire EO]] | ||
| + | [[Category: Zandonatti MA]] | ||
Current revision
Exonuclease domain of Lassa virus nucleoprotein bound to manganese
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