3kij

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[[Image:3kij.jpg|left|200px]]
 
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==Crystal structure of the human PDI-peroxidase==
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The line below this paragraph, containing "STRUCTURE_3kij", creates the "Structure Box" on the page.
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<StructureSection load='3kij' size='340' side='right'caption='[[3kij]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kij]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KIJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3kij| PDB=3kij | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kij OCA], [https://pdbe.org/3kij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kij RCSB], [https://www.ebi.ac.uk/pdbsum/3kij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kij ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GPX8_HUMAN GPX8_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Disulfide bond formation in the endoplasmic reticulum by the sulfhydryl oxidase Ero1 family is thought to be accompanied by the concomitant formation of hydrogen peroxide. Since secretory cells can make substantial amounts of proteins that contain disulfide bonds, the production of this reactive oxygen species could have potentially lethal consequences. Here, we show that two human proteins, GPx7 and GPx8, labeled as secreted glutathione peroxidases, are actually endoplasmic reticulum-resident protein disulfide isomerase peroxidases. In vitro, the addition of GPx7 or GPx8 to a folding protein along with protein disulfide isomerase and peroxide enables the efficient oxidative refolding of a reduced denatured protein. Furthermore, both GPx7 and GPx8 interact with Ero1alpha in vivo, and GPx7 significantly increases oxygen consumption by Ero1alpha in vitro. Hence, GPx7 and GPx8 may represent a novel route for the productive use of peroxide produced by Ero1alpha during disulfide bond formation.
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===Crystal structure of the human PDI-peroxidase===
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Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation.,Nguyen VD, Saaranen MJ, Karala AR, Lappi AK, Wang L, Raykhel IB, Alanen HI, Salo KE, Wang CC, Ruddock LW J Mol Biol. 2011 Feb 25;406(3):503-15. Epub 2011 Jan 5. PMID:21215271<ref>PMID:21215271</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3kij]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIJ OCA].
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<div class="pdbe-citations 3kij" style="background-color:#fffaf0;"></div>
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[[Category: Glutathione peroxidase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nguyen, D V.]]
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[[Category: Large Structures]]
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[[Category: Ruddock, L W.]]
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[[Category: Nguyen DV]]
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[[Category: Ruddock LW]]

Current revision

Crystal structure of the human PDI-peroxidase

PDB ID 3kij

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