3lcm

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[[Image:3lcm.jpg|left|200px]]
 
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==Crystal structure of Smu.1420 from Streptococcus mutans UA159==
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The line below this paragraph, containing "STRUCTURE_3lcm", creates the "Structure Box" on the page.
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<StructureSection load='3lcm' size='340' side='right'caption='[[3lcm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lcm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans_UA159 Streptococcus mutans UA159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LCM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.799&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_3lcm| PDB=3lcm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lcm OCA], [https://pdbe.org/3lcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lcm RCSB], [https://www.ebi.ac.uk/pdbsum/3lcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lcm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8DTD1_STRMU Q8DTD1_STRMU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The smu.1420 gene from the cariogenic pathogen Streptococcus mutans encodes a putative protein which has sequence homology to NQO [ NAD(P)H: quinone oxidoreductase] family members, including mammalian NQO and bacterial MdaB (modulator of drug activity B). NQO can detoxify quinones by converting them to hydroquinones and prevent the generation of reactive oxygen species. Thus, comprehensive studies on Smu.1420 will be important for uncovering the antioxidation and antidrug mechanisms of S. mutans. Here, the catalytic properties of Smu.1420 have been characterized, and its structure was determined in complexes with NADP(+) and menadione, respectively. Smu.1420 binds menadione directly and exhibits a pronounced preference for NADPH over NADH as a substrate, demonstrating that it is an NADPH-specific quinone oxidoreductase. The structure of Smu.1420 shows a compact homodimer with two substrate pockets located in the cleft of the dimer interface. The nicotinamide moiety of NADP(+) is bound on top of the isoalloxazine moiety of the FAD cofactor and overlaps with the binding site of menadione, suggesting a hydride-transfer process from NADPH to FAD and then to menadione. Two strongly basic patches near the substrate pocket are expected to confer the preference for NADPH over NADH. These studies shed light on future drug development against the cariogenic pathogen S. mutans.
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===Crystal structure of Smu.1420 from Streptococcus mutans UA159===
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Structural and biochemical characterization of MdaB from cariogenic Streptococcus mutans reveals an NADPH-specific quinone oxidoreductase.,Wang Z, Li L, Dong YH, Su XD Acta Crystallogr D Biol Crystallogr. 2014 Apr 1;70(Pt 4):912-21. doi:, 10.1107/S1399004713033749. Epub 2014 Mar 19. PMID:24699637<ref>PMID:24699637</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3lcm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCM OCA].
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<div class="pdbe-citations 3lcm" style="background-color:#fffaf0;"></div>
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[[Category: Streptococcus mutans]]
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== References ==
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[[Category: Su, X D.]]
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<references/>
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[[Category: Wang, Z X.]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptococcus mutans UA159]]
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[[Category: Su X-D]]
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[[Category: Wang ZX]]

Current revision

Crystal structure of Smu.1420 from Streptococcus mutans UA159

PDB ID 3lcm

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