3pn1

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[[Image:3pn1.jpg|left|200px]]
 
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==Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo==
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The line below this paragraph, containing "STRUCTURE_3pn1", creates the "Structure Box" on the page.
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<StructureSection load='3pn1' size='340' side='right'caption='[[3pn1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PN1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVH:2-(BUTYLSULFANYL)ADENOSINE'>IVH</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene></td></tr>
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{{STRUCTURE_3pn1| PDB=3pn1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pn1 OCA], [https://pdbe.org/3pn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pn1 RCSB], [https://www.ebi.ac.uk/pdbsum/3pn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pn1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
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===Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo===
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==See Also==
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21189350 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21189350}}
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==About this Structure==
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[[3pn1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PN1 OCA].
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==Reference==
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<ref group="xtra">PMID:21189350</ref><references group="xtra"/>
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Buurman, E.]]
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[[Category: Large Structures]]
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[[Category: Eakin, A.]]
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[[Category: Buurman E]]
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[[Category: Gao, N.]]
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[[Category: Eakin A]]
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[[Category: Huynh, H.]]
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[[Category: Gao N]]
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[[Category: Johnson, K.]]
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[[Category: Huynh H]]
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[[Category: Lahiri, S.]]
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[[Category: Johnson K]]
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[[Category: Mills, S]]
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[[Category: Lahiri S]]
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[[Category: Newman, J.]]
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[[Category: Mills S]]
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[[Category: Shapiro, A.]]
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[[Category: Newman J]]
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[[Category: Stokes, S.]]
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[[Category: Shapiro A]]
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[[Category: Walkup, G.]]
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[[Category: Stokes S]]
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[[Category: Wei, Y.]]
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[[Category: Walkup G]]
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[[Category: Wei Y]]

Current revision

Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo

PDB ID 3pn1

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