3o37

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[[Image:3o37.png|left|200px]]
 
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==Crystal structure of TRIM24 PHD-Bromo complexed with H3(1-10)K4 peptide==
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The line below this paragraph, containing "STRUCTURE_3o37", creates the "Structure Box" on the page.
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<StructureSection load='3o37' size='340' side='right'caption='[[3o37]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o37]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O37 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3o37| PDB=3o37 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o37 OCA], [https://pdbe.org/3o37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o37 RCSB], [https://www.ebi.ac.uk/pdbsum/3o37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o37 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of TRIM24 PHD-Bromo complexed with H3(1-10)K4 peptide===
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== Disease ==
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[https://www.uniprot.org/uniprot/TIF1A_HUMAN TIF1A_HUMAN] Defects in TRIM24 are a cause of thyroid papillary carcinoma (TPC) [MIM:[https://omim.org/entry/188550 188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TRIM24/TIF1 is found in thyroid papillary carcinomas. Translocation t(7;10)(q32;q11) with RET. The translocation generates the TRIM24/RET (PTC6) oncogene.
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== Function ==
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[https://www.uniprot.org/uniprot/TIF1A_HUMAN TIF1A_HUMAN] Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).<ref>PMID:16322096</ref> <ref>PMID:19556538</ref> <ref>PMID:21164480</ref>
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 21164480 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_21164480}}
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</StructureSection>
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==About this Structure==
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[[3o37]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O37 OCA].
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==Reference==
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<ref group="xtra">PMID:21164480</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Patel, D J.]]
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[[Category: Large Structures]]
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[[Category: Wang, Z.]]
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[[Category: Patel DJ]]
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[[Category: Wang Z]]

Current revision

Crystal structure of TRIM24 PHD-Bromo complexed with H3(1-10)K4 peptide

PDB ID 3o37

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