2yrj
From Proteopedia
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| - | [[Image:2yrj.gif|left|200px]]<br /><applet load="2yrj" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2yrj" /> | ||
| - | '''Solution structure of the C2H2-type zinc finger domain (781-813) from zinc finger protein 473'''<br /> | ||
| - | == | + | ==Solution structure of the C2H2-type zinc finger domain (781-813) from zinc finger protein 473== |
| - | + | <StructureSection load='2yrj' size='340' side='right'caption='[[2yrj]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrj OCA], [https://pdbe.org/2yrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrj RCSB], [https://www.ebi.ac.uk/pdbsum/2yrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrj ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrj TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/2yrj_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yrj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hayashi | + | [[Category: Hayashi F]] |
| - | [[Category: Izumi | + | [[Category: Izumi K]] |
| - | [[Category: Qin | + | [[Category: Qin XR]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Yokoyama | + | [[Category: Yoshida M]] |
| - | [[Category: Yoshida | + | |
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Current revision
Solution structure of the C2H2-type zinc finger domain (781-813) from zinc finger protein 473
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Categories: Homo sapiens | Large Structures | Hayashi F | Izumi K | Qin XR | Yokoyama S | Yoshida M
