2y5c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2y5c is ON HOLD until Paper Publication Authors: Webert, H., Hobler, A., Sheftel, A.D., Molik, S., Maestre-Reyna, M., Essen, L.-O., Vorniscescu, D.,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human ferredoxin 2 (Fdx2)in complex with 2Fe2S cluster== | |
| - | + | <StructureSection load='2y5c' size='340' side='right'caption='[[2y5c]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2y5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y5C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5c OCA], [https://pdbe.org/2y5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y5c RCSB], [https://www.ebi.ac.uk/pdbsum/2y5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/FDX2_HUMAN FDX2_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FDX2_HUMAN FDX2_HUMAN] Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).[UniProtKB:Q9H1K1]<ref>PMID:28001042</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bernhardt R]] | ||
| + | [[Category: Essen L-O]] | ||
| + | [[Category: Hannemann F]] | ||
| + | [[Category: Hobler A]] | ||
| + | [[Category: Keusgen M]] | ||
| + | [[Category: Lill R]] | ||
| + | [[Category: Maestre-Reyna M]] | ||
| + | [[Category: Molik S]] | ||
| + | [[Category: Sheftel AD]] | ||
| + | [[Category: Vorniscescu D]] | ||
| + | [[Category: Webert H]] | ||
Current revision
Structure of human ferredoxin 2 (Fdx2)in complex with 2Fe2S cluster
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Categories: Homo sapiens | Large Structures | Bernhardt R | Essen L-O | Hannemann F | Hobler A | Keusgen M | Lill R | Maestre-Reyna M | Molik S | Sheftel AD | Vorniscescu D | Webert H
