3q9c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3q9c is ON HOLD Authors: Lombardi, P.M., Christianson, D.W. Description: Crystal Structure of H159A APAH complexed with N8-acetylspermidine) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of H159A APAH complexed with N8-acetylspermidine== | |
| - | + | <StructureSection load='3q9c' size='340' side='right'caption='[[3q9c]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3q9c]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplana_ramosa Mycoplana ramosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q9C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Q9C:N-{4-[(3-AMINOPROPYL)AMINO]BUTYL}ACETAMIDE'>Q9C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q9c OCA], [https://pdbe.org/3q9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q9c RCSB], [https://www.ebi.ac.uk/pdbsum/3q9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q9c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/APAH_MYCRA APAH_MYCRA] Involved in polyamine metabolism. Catalyzes the deacetylation of various acetylated polyamines such as N-acetylputrescine, N-acetylcadaverine, N(1)-acetylspermine, N(1)-acetylspermidine and N(8)-acetylspermidine (PubMed:8824626, PubMed:3207420). In vitro, is also able to deacetylate L-Lys(epsilon-acetyl)coumarin, but has very low activity towards the larger tetrapeptide N-acetyl-L-Arg-L-His-L-Lys(epsilon-acetyl)-L-Lys(epsilon-acetyl)coumarin (PubMed:21268586).<ref>PMID:21268586</ref> <ref>PMID:3207420</ref> <ref>PMID:8824626</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycoplana ramosa]] | ||
| + | [[Category: Christianson DW]] | ||
| + | [[Category: Lombardi PM]] | ||
Current revision
Crystal Structure of H159A APAH complexed with N8-acetylspermidine
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