3qai
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3qai is ON HOLD Authors: Abad, MC Description: X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 3) |
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 3== | |
| + | <StructureSection load='3qai' size='340' side='right'caption='[[3qai]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QAI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XNN:N~8~-(CYCLOPROPYLMETHYL)-2-(2,6-DIAZASPIRO[3.3]HEPT-2-YL)-N~4~-[2-(METHYLSULFANYL)PHENYL]PYRIMIDO[5,4-D]PYRIMIDINE-4,8-DIAMINE'>XNN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qai OCA], [https://pdbe.org/3qai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qai RCSB], [https://www.ebi.ac.uk/pdbsum/3qai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qai ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Ketohexokinase|Ketohexokinase]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abad MC]] | ||
Current revision
X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 3
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