2ekk

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[[Image:2ekk.jpg|left|200px]]<br /><applet load="2ekk" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ekk" />
 
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'''Solution structure of RUH-074, a human UBA domain'''<br />
 
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==About this Structure==
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==Solution structure of RUH-074, a human UBA domain==
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2EKK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EKK OCA].
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<StructureSection load='2ekk' size='340' side='right'caption='[[2ekk]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2ekk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EKK FirstGlance]. <br>
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[[Category: Hirota, H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Kitasaka, S.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ekk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ekk OCA], [https://pdbe.org/2ekk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ekk RCSB], [https://www.ebi.ac.uk/pdbsum/2ekk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ekk ProSAT], [https://www.topsan.org/Proteins/RSGI/2ekk TOPSAN]</span></td></tr>
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[[Category: Momen, A.Z.M.Ruhul.]]
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</table>
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[[Category: Muto, Y.]]
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== Disease ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN] Defects in HUWE1 are the cause of mental retardation syndromic X-linked Turner type (MRXST) [MIM:[https://omim.org/entry/300706 300706]; also known as mental retardation and macrocephaly syndrome. MRXST shows clinical variability. Associated phenotypes include macrocephaly and variable contractures. A chromosomal microduplication involving HUWE1 and HSD17B10 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:[https://omim.org/entry/300705 300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.<ref>PMID:18252223</ref>
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[[Category: Yokoyama, S.]]
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== Function ==
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[[Category: compact three helix bundle]]
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[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: protein binding]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: uba]]
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[[Category: ubiquitin associated domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:26:06 2008''
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hirota H]]
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[[Category: Kitasaka S]]
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[[Category: Muto Y]]
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[[Category: Ruhul Momen AZM]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of RUH-074, a human UBA domain

PDB ID 2ekk

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