3len

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[[Image:3len.jpg|left|200px]]
 
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==Human Aldose Reductase mutant T113S complexed with Zopolrestat==
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The line below this paragraph, containing "STRUCTURE_3len", creates the "Structure Box" on the page.
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<StructureSection load='3len' size='340' side='right'caption='[[3len]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3len]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LEN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZST:3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE+ACETIC+ACID'>ZST</scene></td></tr>
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{{STRUCTURE_3len| PDB=3len | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3len FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3len OCA], [https://pdbe.org/3len PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3len RCSB], [https://www.ebi.ac.uk/pdbsum/3len PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3len ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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===Human Aldose Reductase mutant T113S complexed with Zopolrestat===
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==See Also==
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3len]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEN OCA].
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Heine, A.]]
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[[Category: Large Structures]]
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[[Category: Klebe, G.]]
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[[Category: Heine A]]
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[[Category: Koch, C.]]
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[[Category: Klebe G]]
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[[Category: Koch C]]

Current revision

Human Aldose Reductase mutant T113S complexed with Zopolrestat

PDB ID 3len

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OCA

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