3prx

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[[Image:3prx.jpg|left|200px]]
 
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==Structure of Complement C5 in Complex with CVF and SSL7==
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The line below this paragraph, containing "STRUCTURE_3prx", creates the "Structure Box" on the page.
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<StructureSection load='3prx' size='340' side='right'caption='[[3prx]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3prx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3prx| PDB=3prx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3prx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prx OCA], [https://pdbe.org/3prx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3prx RCSB], [https://www.ebi.ac.uk/pdbsum/3prx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3prx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D3JIB2_STAAU D3JIB2_STAAU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Complement acts as a danger-sensing system in the innate immune system, and its activation initiates a strong inflammatory response and cleavage of the proteins C3 and C5 by proteolytic enzymes, the convertases. These contain a non-catalytic substrate contacting subunit (C3b or C4b) in complex with a protease subunit (Bb or C2a). We determined the crystal structures of the C3b homologue cobra venom factor (CVF) in complex with C5, and in complex with C5 and the inhibitor SSL7 at 4.3 A resolution. The structures reveal a parallel two-point attachment between C5 and CVF, where the presence of SSL7 only slightly affects the C5-CVF interface, explaining the IgA dependence for SSL7-mediated inhibition of C5 cleavage. CVF functions as a relatively rigid binding scaffold inducing a conformational change in C5, which positions its cleavage site in proximity to the serine protease Bb. A general model for substrate recognition by the convertases is presented based on the C5-CVF and C3b-Bb-SCIN structures. Prior knowledge concerning interactions between the endogenous convertases and their substrates is rationalized by this model.
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===Structure of Complement C5 in Complex with CVF and SSL7===
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Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.,Laursen NS, Andersen KR, Braren I, Spillner E, Sottrup-Jensen L, Andersen GR EMBO J. 2011 Jan 7. PMID:21217642<ref>PMID:21217642</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3prx" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21217642}}, adds the Publication Abstract to the page
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*[[Cobra venom factor|Cobra venom factor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21217642 is the PubMed ID number.
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*[[Complement C5 3D structures|Complement C5 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_21217642}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3prx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRX OCA].
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==Reference==
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<ref group="xtra">PMID:21217642</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Naja kaouthia]]
[[Category: Naja kaouthia]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Andersen, G R.]]
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[[Category: Andersen GR]]
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[[Category: Andersen, K R.]]
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[[Category: Andersen KR]]
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[[Category: Braren, I.]]
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[[Category: Braren I]]
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[[Category: Laursen, N S.]]
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[[Category: Laursen NS]]
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[[Category: Sottrup-Jensen, L.]]
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[[Category: Sottrup-Jensen L]]
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[[Category: Spillner, E.]]
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[[Category: Spillner E]]

Current revision

Structure of Complement C5 in Complex with CVF and SSL7

PDB ID 3prx

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