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3p5d

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[[Image:3p5d.png|left|200px]]
 
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==Structure of the carbohydrate-recognition domain of human Langerin with man5 (Man alpha1-3(Man alpha1-6)Man alpha1-6)(Man- alpha1-3)Man==
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The line below this paragraph, containing "STRUCTURE_3p5d", creates the "Structure Box" on the page.
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<StructureSection load='3p5d' size='340' side='right'caption='[[3p5d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P5D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8013&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900112:3alpha-alpha-mannobiose'>PRD_900112</scene></td></tr>
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{{STRUCTURE_3p5d| PDB=3p5d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5d OCA], [https://pdbe.org/3p5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p5d RCSB], [https://www.ebi.ac.uk/pdbsum/3p5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5d ProSAT]</span></td></tr>
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</table>
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===Structure of the carbohydrate-recognition domain of human Langerin with man5 (Man alpha1-3(Man alpha1-6)Man alpha1-6)(Man- alpha1-3)Man===
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== Disease ==
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[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 21112338 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_21112338}}
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</StructureSection>
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==About this Structure==
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[[3p5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5D OCA].
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==Reference==
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<ref group="xtra">PMID:21112338</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Drickamer, K.]]
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[[Category: Large Structures]]
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[[Category: Feinberg, H.]]
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[[Category: Drickamer K]]
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[[Category: Graham, S A.]]
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[[Category: Feinberg H]]
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[[Category: Knirel, Y A.]]
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[[Category: Graham SA]]
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[[Category: McBride, R.]]
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[[Category: Knirel YA]]
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[[Category: Razi, N.]]
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[[Category: McBride R]]
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[[Category: Taylor, M E.]]
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[[Category: Razi N]]
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[[Category: Weis, W I.]]
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[[Category: Taylor ME]]
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[[Category: Weis WI]]

Current revision

Structure of the carbohydrate-recognition domain of human Langerin with man5 (Man alpha1-3(Man alpha1-6)Man alpha1-6)(Man- alpha1-3)Man

PDB ID 3p5d

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