3pmx

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[[Image:3pmx.png|left|200px]]
 
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==Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator==
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The line below this paragraph, containing "STRUCTURE_3pmx", creates the "Structure Box" on the page.
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<StructureSection load='3pmx' size='340' side='right'caption='[[3pmx]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pmx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PMX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=808:N-[(2S)-5-{[5-(TRIFLUOROMETHYL)FURAN-2-YL]METHYL}-2,3-DIHYDRO-1H-INDEN-2-YL]PROPANE-2-SULFONAMIDE'>808</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3pmx| PDB=3pmx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pmx OCA], [https://pdbe.org/3pmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pmx RCSB], [https://www.ebi.ac.uk/pdbsum/3pmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pmx ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.
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===Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator===
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Structure based evolution of a novel series of positive modulators of the AMPA receptor.,Jamieson C, Maclean JK, Brown CI, Campbell RA, Gillen KJ, Gillespie J, Kazemier B, Kiczun M, Lamont Y, Lyons AJ, Moir EM, Morrow JA, Pantling J, Rankovic Z, Smith L Bioorg Med Chem Lett. 2011 Jan 15;21(2):805-11. Epub 2010 Nov 25. PMID:21190850<ref>PMID:21190850</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pmx" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21190850}}, adds the Publication Abstract to the page
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21190850 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21190850}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3pmx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMX OCA].
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==Reference==
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<ref group="xtra">PMID:21190850</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Brown, C I.]]
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[[Category: Brown CI]]
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[[Category: Campbell, R A.]]
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[[Category: Campbell RA]]
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[[Category: Gillen, K J.]]
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[[Category: Gillen KJ]]
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[[Category: Gillespie, J.]]
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[[Category: Gillespie J]]
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[[Category: Jamieson, C.]]
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[[Category: Jamieson C]]
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[[Category: Kazemier, B.]]
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[[Category: Kazemier B]]
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[[Category: Kiczun, M.]]
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[[Category: Kiczun M]]
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[[Category: Lamont, Y.]]
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[[Category: Lamont Y]]
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[[Category: Lyons, A J.]]
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[[Category: Lyons AJ]]
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[[Category: Maclean, J K.F.]]
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[[Category: Maclean JKF]]
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[[Category: Moir, E M.]]
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[[Category: Moir EM]]
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[[Category: Morrow, J A.]]
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[[Category: Morrow JA]]
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[[Category: Pantling, J.]]
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[[Category: Pantling J]]
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[[Category: Rankovic, Z.]]
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[[Category: Rankovic Z]]
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[[Category: Smith, L.]]
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[[Category: Smith L]]

Current revision

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

PDB ID 3pmx

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