2ksk

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[[Image:2ksk.jpg|left|200px]]
 
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==Solution Structure of Sugarcane defensin 5==
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The line below this paragraph, containing "STRUCTURE_2ksk", creates the "Structure Box" on the page.
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<StructureSection load='2ksk' size='340' side='right'caption='[[2ksk]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ksk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharum_officinarum Saccharum officinarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KSK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ksk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ksk OCA], [https://pdbe.org/2ksk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ksk RCSB], [https://www.ebi.ac.uk/pdbsum/2ksk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ksk ProSAT]</span></td></tr>
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{{STRUCTURE_2ksk| PDB=2ksk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/F2Z241_SACOF F2Z241_SACOF]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. Sd5 is a recently described antifungal defensin that appears to be the result of a recent gain of function. We reported here the solution NMR structure of Sd5 and characterized the backbone dynamics in the free state and in the presence of membrane models. (15)N relaxation dispersion measurements indicate intrinsic conformational exchange processes, showing two clear distinct k(ex), 490 and 1800 s(-1). These multiple motions may be related to transient twisting or breathing of the alpha helix and beta sheet. The stages of membrane recognition and disruption by Sd5 over a large timescale range were mapped and demonstrated that Sd5 in solution sampled an ensemble of different conformations, of which a subset is selected upon membrane binding. Defensins share similar structures, but we demonstrated here that their dynamics can be extremely diverse.
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===Solution Structure of Sugarcane defensin 5===
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Portrayal of Complex Dynamic Properties of Sugarcane Defensin 5 by NMR: Multiple Motions Associated with Membrane Interaction.,de Paula VS, Razzera G, Barreto-Bergter E, Almeida FC, Valente AP Structure. 2011 Jan 12;19(1):26-36. PMID:21220113<ref>PMID:21220113</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ksk" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21220113}}, adds the Publication Abstract to the page
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*[[Defensin 3D structures|Defensin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21220113 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21220113}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2ksk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharum_officinarum Saccharum officinarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KSK OCA].
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==Reference==
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<ref group="xtra">PMID:21220113</ref><references group="xtra"/>
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[[Category: Saccharum officinarum]]
[[Category: Saccharum officinarum]]
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[[Category: Almeida, F C.L.]]
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[[Category: Almeida FCL]]
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[[Category: Paula, V S.de.]]
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[[Category: Valente A]]
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[[Category: Valente, A.]]
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[[Category: De Paula VS]]

Current revision

Solution Structure of Sugarcane defensin 5

PDB ID 2ksk

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