2xz2

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[[Image:2xz2.jpg|left|200px]]
 
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==Crystal structure of CstF-50 homodimerization domain==
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The line below this paragraph, containing "STRUCTURE_2xz2", creates the "Structure Box" on the page.
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<StructureSection load='2xz2' size='340' side='right'caption='[[2xz2]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_2xz2| PDB=2xz2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz2 OCA], [https://pdbe.org/2xz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xz2 RCSB], [https://www.ebi.ac.uk/pdbsum/2xz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz2 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Cleavage stimulation Factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognizes U and G/U-rich cis-acting RNA sequence elements and helps stabilize the Cleavage and Polyadenylation Specificity Factor (CPSF) at the polyadenylation site as required for productive RNA cleavage. Here, we describe the crystal structure of the N-terminal domain of Drosophila CstF-50 subunit. It forms a compact homodimer that exposes two geometrically opposite, identical, and conserved surfaces that may serve as binding platform. Together with previous data on the structure of CstF-77, homodimerization of CstF-50 N-terminal domain supports the model in which the functional state of CstF is a heterohexamer.
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===CRYSTAL STRUCTURE OF CSTF-50 HOMODIMERIZATION DOMAIN===
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Hexameric architecture of CstF supported by CstF-50 homodimerization domain structure.,Moreno-Morcillo M, Minvielle-Sebastia L, Mackereth C, Fribourg S RNA. 2011 Jan 13. PMID:21233223<ref>PMID:21233223</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21233223}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2xz2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21233223 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21233223}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2xz2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ2 OCA].
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==Reference==
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<ref group="xtra">PMID:21233223</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Fribourg, S.]]
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[[Category: Large Structures]]
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[[Category: Moreno-Morcillo, M.]]
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[[Category: Fribourg S]]
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[[Category: Moreno-Morcillo M]]

Current revision

Crystal structure of CstF-50 homodimerization domain

PDB ID 2xz2

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