This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3myo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:41, 1 November 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3myo.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes==
-
The line below this paragraph, containing "STRUCTURE_3myo", creates the "Structure Box" on the page.
+
<StructureSection load='3myo' size='340' side='right'caption='[[3myo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3myo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MYO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3myo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3myo OCA], [https://pdbe.org/3myo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3myo RCSB], [https://www.ebi.ac.uk/pdbsum/3myo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3myo ProSAT]</span></td></tr>
-
{{STRUCTURE_3myo| PDB=3myo | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LACD1_STRP1 LACD1_STRP1]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Staphylococcus aureus LacD, a Class I tagatose-1,6-bisphosphate (TBP) aldolase, shows broadened substrate specificity by catalyzing the cleavage of 1,6-bisphosphate derivatives of d-tagatose, d-fructose, d-sorbose, and d-psicose. LacD.1 and LacD.2 are two closely-related Class I TBP aldolases in Streptococcus pyogenes. Here we have determined the crystal structures of S. aureus LacD and S. pyogenes LacD.1. Monomers of both enzymes are folded into a (beta/alpha)(8) barrel and two monomers associate tightly to form a dimer in the crystals. The structures suggest that the residues E189 and S300 of rabbit muscle Class I fructose-1,6-bisphosphate (FBP) aldolase are important for substrate specificity. When we mutated the corresponding residues of S. aureus LacD, the mutants (L165E, L275S, and L165E/L275S) showed enhanced substrate specificity toward FBP. STRUCTURED SUMMARY: lacDbinds to lacD by X-ray crystallography(View interaction) lacD1binds to lacD1 by X-ray crystallography(View interaction).
-
===Crystal structure of tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes===
+
Crystal structures of LacD from Staphylococcus aureus and LacD.1 from Streptococcus pyogenes: Insights into substrate specificity and virulence gene regulation.,Lee SJ, Kim HS, Kim do J, Yoon HJ, Kim KH, Yoon JY, Suh SW FEBS Lett. 2011 Jan 21;585(2):307-12. Epub 2010 Dec 28. PMID:21192932<ref>PMID:21192932</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3myo" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_21192932}}, adds the Publication Abstract to the page
+
*[[Aldolase 3D structures|Aldolase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 21192932 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21192932}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3myo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYO OCA].
+
[[Category: Streptococcus pyogenes serotype M1]]
-
 
+
[[Category: Kim DJ]]
-
==Reference==
+
[[Category: Kim HS]]
-
<ref group="xtra">PMID:21192932</ref><references group="xtra"/>
+
[[Category: Kim KH]]
-
[[Category: Streptococcus pyogenes]]
+
[[Category: Lee SJ]]
-
[[Category: Tagatose-bisphosphate aldolase]]
+
[[Category: Suh SW]]
-
[[Category: Kim, D J.]]
+
[[Category: Yoon HJ]]
-
[[Category: Kim, H S.]]
+
[[Category: Yoon JY]]
-
[[Category: Kim, K H.]]
+
-
[[Category: Lee, S J.]]
+
-
[[Category: Suh, S W.]]
+
-
[[Category: Yoon, H J.]]
+
-
[[Category: Yoon, J Y.]]
+

Current revision

Crystal structure of tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes

PDB ID 3myo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3myo"
Personal tools