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Aldose Reductase
From Proteopedia
(Difference between revisions)
(New page: Crystal structure of Aldose Reductase 2bgq {{STRUCTURE_2bgq| PDB=2bgq | SIZE=300| SCENE= |right|CAPTION=Aldose Reductase 2bgq }} [[Aldose Red...) |
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| - | + | <StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'> | |
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| - | + | == Function == | |
| - | + | [[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.<ref>PMID:1734286</ref> | |
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| - | == | + | == Disease == |
| + | The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. | ||
| - | == | + | == Structural highlights == |
| - | + | AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref> | |
| - | + | *<scene name='43/436098/Cv/7'>Active site interactions</scene>. Water molecules are shown as red spheres. | |
| - | + | *<scene name='43/436098/Cv/9'>Active site tunnel</scene>. | |
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| - | ===Aldose | + | == 3D Structures of aldose reductase == |
| + | [[Aldose reductase 3D structures]] | ||
| - | + | </StructureSection> | |
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| - | + | == References == | |
| - | + | <references/> | |
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References
- ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
- ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098
