2kvd

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[[Image:2kvd.png|left|200px]]
 
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==Mesencephalic astrocyte-derived neurotrophic factor (MANF)==
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The line below this paragraph, containing "STRUCTURE_2kvd", creates the "Structure Box" on the page.
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<StructureSection load='2kvd' size='340' side='right'caption='[[2kvd]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvd OCA], [https://pdbe.org/2kvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvd RCSB], [https://www.ebi.ac.uk/pdbsum/2kvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvd ProSAT]</span></td></tr>
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{{STRUCTURE_2kvd| PDB=2kvd | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson's disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well-known inhibitor of pro-apoptotic Bcl-2-associated X protein (Bax). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
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===Mesencephalic astrocyte-derived neurotrophic factor (MANF)===
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Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons.,Hellman M, Arumae U, Yu LY, Lindholm P, Peranen J, Saarma M, Permi P J Biol Chem. 2010 Nov 3. PMID:21047780<ref>PMID:21047780</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21047780}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kvd" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21047780 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21047780}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2kvd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVD OCA].
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==Reference==
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<ref group="xtra">PMID:21047780</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hellman, M H.]]
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[[Category: Large Structures]]
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[[Category: Peranen, J.]]
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[[Category: Hellman MH]]
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[[Category: Permi, P.]]
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[[Category: Peranen J]]
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[[Category: Saarma, M.]]
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[[Category: Permi P]]
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[[Category: Saarma M]]

Current revision

Mesencephalic astrocyte-derived neurotrophic factor (MANF)

PDB ID 2kvd

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