3mm0

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[[Image:3mm0.png|left|200px]]
 
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==Crystal structure of chimeric avidin==
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The line below this paragraph, containing "STRUCTURE_3mm0", creates the "Structure Box" on the page.
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<StructureSection load='3mm0' size='340' side='right'caption='[[3mm0]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mm0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MM0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mm0 OCA], [https://pdbe.org/3mm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mm0 RCSB], [https://www.ebi.ac.uk/pdbsum/3mm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mm0 ProSAT]</span></td></tr>
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{{STRUCTURE_3mm0| PDB=3mm0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AVR4_CHICK AVR4_CHICK] [https://www.uniprot.org/uniprot/AVID_CHICK AVID_CHICK] The biological function of avidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of avidin).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Avidin and its bacterial analogue streptavidin have been widely used in applications in life sciences. Recently, we described a highly thermostable engineered avidin, called chimeric avidin, which is a hybrid of avidin and avidin related protein 4. Here we report a protocol for pilot-scale production in E. coli and the X-ray structure of the Ile117Tyr mutant of chimeric avidin. The ligand-binding properties of chimeric avidin were explored with isothermal titration calorimetry. We found chimeric avidin to be more stable against various harsh organic solvents at elevated temperatures compared to avidin and streptavidin. The properties of chimeric avidin make it a potential tool for new applications in biotechnology. (c) 2010 Wiley Periodicals, Inc.
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===Crystal structure of chimeric avidin===
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Chimeric avidin shows stability against harsh chemical conditions - biochemical analysis and 3D structure.,Maatta JA, Eisenberg-Domovich Y, Nordlund HR, Hayouka R, Kulomaa MS, Livnah O, Hytonen VP Biotechnol Bioeng. 2010 Oct 11. PMID:20939005<ref>PMID:20939005</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20939005}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3mm0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20939005 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20939005}}
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==About this Structure==
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[[3mm0]] is a 12 chain structure of [[Avidin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MM0 OCA].
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==See Also==
==See Also==
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*[[Avidin]]
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*[[Avidin 3D structures|Avidin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20939005</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Eisenberg-Domovich, Y.]]
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[[Category: Large Structures]]
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[[Category: Hytonen, V P.]]
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[[Category: Eisenberg-Domovich Y]]
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[[Category: Kulomaa, M S.]]
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[[Category: Hytonen VP]]
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[[Category: Livnah, O.]]
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[[Category: Kulomaa MS]]
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[[Category: Maatta, J A.E.]]
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[[Category: Livnah O]]
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[[Category: Nordlund, H R.]]
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[[Category: Maatta JAE]]
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[[Category: Nordlund HR]]

Current revision

Crystal structure of chimeric avidin

PDB ID 3mm0

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