2kve

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[[Image:2kve.png|left|200px]]
 
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==C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF)==
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The line below this paragraph, containing "STRUCTURE_2kve", creates the "Structure Box" on the page.
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<StructureSection load='2kve' size='340' side='right'caption='[[2kve]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kve OCA], [https://pdbe.org/2kve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kve RCSB], [https://www.ebi.ac.uk/pdbsum/2kve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kve ProSAT]</span></td></tr>
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{{STRUCTURE_2kve| PDB=2kve | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Familial pancreatic carcinoma.
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== Function ==
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson's disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well-known inhibitor of pro-apoptotic Bcl-2-associated X protein (Bax). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
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===C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF)===
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Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons.,Hellman M, Arumae U, Yu LY, Lindholm P, Peranen J, Saarma M, Permi P J Biol Chem. 2010 Nov 3. PMID:21047780<ref>PMID:21047780</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21047780}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kve" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21047780 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21047780}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2kve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVE OCA].
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==Reference==
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<ref group="xtra">PMID:21047780</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hellman, M H.]]
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[[Category: Large Structures]]
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[[Category: Permi, P.]]
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[[Category: Hellman MH]]
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[[Category: Saarma, M.]]
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[[Category: Permi P]]
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[[Category: Saarma M]]

Current revision

C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF)

PDB ID 2kve

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