3qf3

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(New page: '''Unreleased structure''' The entry 3qf3 is ON HOLD Authors: Blasco, B., Pojer, F., Cole, S.T. Description: Crystal structure of EspR transcription factor from mycobacterium tuberculo...)
Current revision (10:47, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3qf3 is ON HOLD
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==Crystal structure of EspR transcription factor from mycobacterium tuberculosis==
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<StructureSection load='3qf3' size='340' side='right'caption='[[3qf3]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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Authors: Blasco, B., Pojer, F., Cole, S.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qf3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QF3 FirstGlance]. <br>
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Description: Crystal structure of EspR transcription factor from mycobacterium tuberculosis
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qf3 OCA], [https://pdbe.org/3qf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qf3 RCSB], [https://www.ebi.ac.uk/pdbsum/3qf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qf3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Blasco B]]
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[[Category: Cole ST]]
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[[Category: Pojer F]]

Current revision

Crystal structure of EspR transcription factor from mycobacterium tuberculosis

PDB ID 3qf3

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