3qfv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==MRCK beta in complex with TPCA-1== | |
| + | <StructureSection load='3qfv' size='340' side='right'caption='[[3qfv]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qfv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QFV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NM7:2-(CARBAMOYLAMINO)-5-(4-FLUOROPHENYL)THIOPHENE-3-CARBOXAMIDE'>NM7</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qfv OCA], [https://pdbe.org/3qfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qfv RCSB], [https://www.ebi.ac.uk/pdbsum/3qfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qfv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MRCKB_HUMAN MRCKB_HUMAN] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:21949762</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boakes A]] | ||
| + | [[Category: Crighton D]] | ||
| + | [[Category: Heikkila TJ]] | ||
| + | [[Category: Kaye SJ]] | ||
| + | [[Category: Mezna M]] | ||
| + | [[Category: Olson MF]] | ||
| + | [[Category: Pang L]] | ||
| + | [[Category: Rushbrooke M]] | ||
| + | [[Category: Schroder E]] | ||
| + | [[Category: Turnbull A]] | ||
| + | [[Category: Wheatley E]] | ||
Current revision
MRCK beta in complex with TPCA-1
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Categories: Homo sapiens | Large Structures | Boakes A | Crighton D | Heikkila TJ | Kaye SJ | Mezna M | Olson MF | Pang L | Rushbrooke M | Schroder E | Turnbull A | Wheatley E
