3qi2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco== | |
| - | + | <StructureSection load='3qi2' size='340' side='right'caption='[[3qi2]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qi2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.797Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi2 OCA], [https://pdbe.org/3qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bosch DE]] | ||
| + | [[Category: Kimple AJ]] | ||
| + | [[Category: Miley MJ]] | ||
| + | [[Category: Siderovski DP]] | ||
| + | [[Category: Willard FS]] | ||
Current revision
A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
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