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3qiu
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3qiu is ON HOLD Authors: Kruse, A.C., Ely, L.K., Newell, E.W., Davis, M.M., Garcia, K.C. Description: Crystal structure of the 226 TCR in complex w...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the 226 TCR in complex with MCC/I-Ek== | |
| + | <StructureSection load='3qiu' size='340' side='right'caption='[[3qiu]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qiu]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Carolina_sphinx Carolina sphinx] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIU FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-Eb1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qiu OCA], [https://pdbe.org/3qiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qiu RCSB], [https://www.ebi.ac.uk/pdbsum/3qiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qiu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/CYC_MANSE CYC_MANSE]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | T cells specific for the cytochrome c Ag are widely used to investigate many aspects of TCR specificity and interactions with peptide-MHC, but structural information has long been elusive. In this study, we present structures for the well-studied 2B4 TCR, as well as a naturally occurring variant of the 5c.c7 TCR, 226, which is cross-reactive with more than half of possible substitutions at all three TCR-sensitive residues on the peptide Ag. These structures alone and in complex with peptide-MHC ligands allow us to reassess many prior mutagenesis results. In addition, the structure of 226 bound to one peptide variant, p5E, shows major changes in the CDR3 contacts compared with wild-type, yet the TCR V-region contacts with MHC are conserved. These and other data illustrate the ability of TCRs to accommodate large variations in CDR3 structure and peptide contacts within the constraints of highly conserved TCR-MHC interactions. | ||
| - | + | Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-E.,Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM J Immunol. 2011 Apr 13. PMID:21490152<ref>PMID:21490152</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3qiu" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[MHC 3D structures|MHC 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Carolina sphinx]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
| + | [[Category: Davis, M M]] | ||
| + | [[Category: Ely, L K]] | ||
| + | [[Category: Garcia, K C]] | ||
| + | [[Category: Kruse, A C]] | ||
| + | [[Category: Newell, E W]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunoglobulin domain]] | ||
| + | [[Category: Mhc molecule]] | ||
| + | [[Category: T cell receptor]] | ||
Current revision
Crystal structure of the 226 TCR in complex with MCC/I-Ek
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