3mk3

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[[Image:3mk3.jpg|left|200px]]
 
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==Crystal structure of Lumazine synthase from Salmonella typhimurium LT2==
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The line below this paragraph, containing "STRUCTURE_3mk3", creates the "Structure Box" on the page.
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<StructureSection load='3mk3' size='340' side='right'caption='[[3mk3]], [[Resolution|resolution]] 3.57&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mk3]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MK3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.569&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3mk3| PDB=3mk3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mk3 OCA], [https://pdbe.org/3mk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3mk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mk3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RISB_SALTY RISB_SALTY] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Riboflavin biosynthesis is an essential pathway in bacteria, in contrast to animals, which obtain riboflavin from their diet. Therefore, the enzymes involved in the riboflavin-biosynthesis pathway are potential targets for the development of antibacterial drugs. Lumazine synthase, an enzyme that is involved in the penultimate step of riboflavin biosynthesis, catalyzes the formation of 6,7-dimethyl-8-ribityllumazine from 3,4-dihydroxy-2-butanone 4-phosphate and 5-amino-6-ribitylamino-2,4-(1H,3H)-pyrimidinedione. Lumazine synthase from Salmonella typhimurium (sLS) has been cloned, overexpressed, purified and was crystallized in three forms, each with different crystal packing. The crystal structure of sLS in the monoclinic space group P2(1) has been determined with 60 subunits per asymmetric unit, packed as an icosahedron, at 3.57 A resolution. Interestingly, sLS contains an N-terminal proline residue (Pro11) which had previously been suggested to disrupt the formation of the icosohedral assembly. In addition, comparison of the structure of sLS with known orthologous lumazine synthase structures allowed identification of the amino-acid residues involved in substrate binding and catalysis. The sLS structure reported here could serve as a starting point for the development of species-specific antibacterial drugs.
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===Crystal structure of Lumazine synthase from Salmonella typhimurium LT2===
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Crystal structure analysis of icosahedral lumazine synthase from Salmonella typhimurium, an antibacterial drug target.,Kumar P, Singh M, Karthikeyan S Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):131-9. Epub 2011, Jan 15. PMID:21245535<ref>PMID:21245535</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21245535}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3mk3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21245535 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21245535}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3mk3]] is a 60 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK3 OCA].
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Karthikeyan S]]
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==Reference==
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[[Category: Kumar P]]
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<ref group="xtra">PMID:21245535</ref><references group="xtra"/>
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[[Category: Singh M]]
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[[Category: Riboflavin synthase]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Karthikeyan, S.]]
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[[Category: Kumar, P.]]
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[[Category: Singh, M.]]
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Current revision

Crystal structure of Lumazine synthase from Salmonella typhimurium LT2

PDB ID 3mk3

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