3o8l

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[[Image:3o8l.jpg|left|200px]]
 
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==Structure of phosphofructokinase from rabbit skeletal muscle==
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The line below this paragraph, containing "STRUCTURE_3o8l", creates the "Structure Box" on the page.
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<StructureSection load='3o8l' size='340' side='right'caption='[[3o8l]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o8l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O8L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3o8l| PDB=3o8l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o8l OCA], [https://pdbe.org/3o8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o8l RCSB], [https://www.ebi.ac.uk/pdbsum/3o8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o8l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PFKAM_RABIT PFKAM_RABIT] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03184]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phosphofructokinase 1 (PFK) is a multisubunit allosteric enzyme that catalyzes the principal regulatory step in glycolysis-the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate by ATP. The activity of eukaryotic PFK is modulated by a number of effectors in response to the cell's needs for energy and building blocks for biosynthesis. The crystal structures of eukaryotic PFKs-from Saccharomyces cerevisiae and rabbit skeletal muscle-demonstrate how successive gene duplications and fusion are reflected in the protein structure and how they allow the evolution of new functionalities. The basic framework inherited from prokaryotes is conserved, and additional levels of structural and functional complexity have evolved around it. Analysis of protein-ligand complexes has shown how PFK is activated by fructose 2,6-bisphosphate (a powerful PFK effector found only in eukaryotes) and reveals a novel nucleotide binding site. Crystallographic results have been used as the basis for structure-based effector design.
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===Structure of phosphofructokinase from rabbit skeletal muscle===
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The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.,Banaszak K, Mechin I, Obmolova G, Oldham M, Chang SH, Ruiz T, Radermacher M, Kopperschlager G, Rypniewski W J Mol Biol. 2011 Jan 15. PMID:21241708<ref>PMID:21241708</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3o8l" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21241708 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21241708}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3o8l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8L OCA].
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==Reference==
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<ref group="xtra">PMID:21241708</ref><references group="xtra"/>
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[[Category: 6-phosphofructokinase]]
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Banaszak, K.]]
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[[Category: Banaszak K]]
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[[Category: Chang, S H.]]
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[[Category: Chang SH]]
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[[Category: Rypniewski, W.]]
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[[Category: Rypniewski W]]

Current revision

Structure of phosphofructokinase from rabbit skeletal muscle

PDB ID 3o8l

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