2l5y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:53, 1 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2l5y.png|left|200px]]
 
-
<!--
+
==NMR structure of calcium-loaded STIM2 EF-SAM.==
-
The line below this paragraph, containing "STRUCTURE_2l5y", creates the "Structure Box" on the page.
+
<StructureSection load='2l5y' size='340' side='right'caption='[[2l5y]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2l5y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5Y FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
{{STRUCTURE_2l5y| PDB=2l5y | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5y OCA], [https://pdbe.org/2l5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5y RCSB], [https://www.ebi.ac.uk/pdbsum/2l5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5y ProSAT]</span></td></tr>
-
 
+
</table>
-
===NMR structure of calcium-loaded STIM2 EF-SAM.===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/STIM2_HUMAN STIM2_HUMAN] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.<ref>PMID:16005298</ref> <ref>PMID:16860747</ref> <ref>PMID:17905723</ref> <ref>PMID:18160041</ref> <ref>PMID:21217057</ref> <ref>PMID:22464749</ref> <ref>PMID:23359669</ref>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21217057}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 21217057 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_21217057}}
+
-
 
+
-
==About this Structure==
+
-
[[2l5y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5Y OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:21217057</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ikura, M.]]
+
[[Category: Large Structures]]
-
[[Category: Stathopulos, P B.]]
+
[[Category: Ikura M]]
-
[[Category: Zheng, L.]]
+
[[Category: Stathopulos PB]]
 +
[[Category: Zheng L]]

Current revision

NMR structure of calcium-loaded STIM2 EF-SAM.

PDB ID 2l5y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l5y"
Personal tools