3qi3

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'''Unreleased structure'''
 
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The entry 3qi3 is ON HOLD
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==Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691==
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<StructureSection load='3qi3' size='340' side='right'caption='[[3qi3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qi3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDB:1-(2-CHLOROPHENYL)-6-[(2R)-3,3,3-TRIFLUORO-2-METHYLPROPYL]-1,7-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE'>PDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi3 OCA], [https://pdbe.org/3qi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi3 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
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Authors: Hou, J., Xu, J., Liu, M., Zhao, R., Lou, H., Ke, H.
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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Description: Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hou J]]
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[[Category: Ke H]]
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[[Category: Liu M]]
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[[Category: Lou H]]
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[[Category: Xu J]]
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[[Category: Zhao R]]

Current revision

Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691

PDB ID 3qi3

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