3qj7
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3qj7 is ON HOLD Authors: Reddy, M.C.M., Bruning, J.B., Harshbarger, W., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC) Description: C...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP== | |
| + | <StructureSection load='3qj7' size='340' side='right'caption='[[3qj7]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qj7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJ7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qj7 OCA], [https://pdbe.org/3qj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qj7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qj7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Bruning JB]] | ||
| + | [[Category: Harshbarger W]] | ||
| + | [[Category: Reddy MCM]] | ||
| + | [[Category: Sacchettini JC]] | ||
Current revision
Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP
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