2jso

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(New page: 200px<br /><applet load="2jso" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jso" /> '''Antimicrobial resistance protein'''<br /> =...)
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[[Image:2jso.gif|left|200px]]<br /><applet load="2jso" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2jso" />
 
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'''Antimicrobial resistance protein'''<br />
 
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==Overview==
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==Antimicrobial resistance protein==
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PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that, allow the Gram-negative bacteria to survive the cationic antimicrobial, peptide polymyxin B. The two TCSs are linked by the polymyxin resistance, protein, PmrD. The PhoP-activated PmrD protects the phosphorylated, response regulator PmrA from dephosphorylation, and promotes the, transcription of PmrA-activated genes responsible for polymyxin, resistance. PmrD is the first protein identified to mediate the, connectivity between two TCSs by protecting the phosphorylated response, regulator of the downstream TCS. PmrD shows no homology to proteins with, known structures. We present here the solution structure of PmrD from, Escherichia coli, the first three-dimensional structure of the PmrD, family. Our study provides the structural basis of the novel interacting, mechanism of bacterial two-component signal-transduction systems.
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<StructureSection load='2jso' size='340' side='right'caption='[[2jso]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2jso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSO FirstGlance]. <br>
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2JSO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jso OCA], [https://pdbe.org/2jso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jso RCSB], [https://www.ebi.ac.uk/pdbsum/2jso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jso ProSAT]</span></td></tr>
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==Reference==
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</table>
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First structure of the polymyxin resistance proteins., Fu W, Yang F, Kang X, Zhang X, Li Y, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Oct 5;361(4):1033-7. Epub 2007 Aug 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17686460 17686460]
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== Function ==
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[[Category: Escherichia coli]]
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[https://www.uniprot.org/uniprot/PMRD_ECOLI PMRD_ECOLI] Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates.
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[[Category: Single protein]]
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== Evolutionary Conservation ==
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[[Category: Fu, W.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Jin, C.]]
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Check<jmol>
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[[Category: antibiotic resistance]]
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<jmolCheckbox>
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[[Category: protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jso_consurf.spt"</scriptWhenChecked>
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[[Category: signaling protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: transcription]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:45:58 2008''
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jso ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Fu W]]
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[[Category: Jin C]]

Current revision

Antimicrobial resistance protein

PDB ID 2jso

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