Colicin Js
From Proteopedia
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==Synthesis and release== | ==Synthesis and release== | ||
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| + | The operon for colicin B is encoded on a plasmid in the cytoplasm of the ''E. coli''. This operon also encodes its [[Colicin Immunity Protein]], [[Cji]], to protect the cell from the cytotoxic activities of the colicin, alongside a protein to aid the release of the colicin outside the cell. | ||
==Mechanism of uptake== | ==Mechanism of uptake== | ||
| - | == | + | The receptor binding domain of the colicin binds to the outer membrane receptor CjrBC<ref> PMID: 12423780 </ref> on the target cell; it is a constitutively expressed protein parasitised by the colicin. The translocation domain then recruits proteins from the [[Ton]] system to translocate the protein across the membrane and into the cytoplasm. |
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| + | ==References== | ||
| + | <references/> | ||
Current revision
Colicin Js is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them with its cytotoxic domain; its method of killing is as yet unidentified.
Synthesis and release
The operon for colicin B is encoded on a plasmid in the cytoplasm of the E. coli. This operon also encodes its Colicin Immunity Protein, Cji, to protect the cell from the cytotoxic activities of the colicin, alongside a protein to aid the release of the colicin outside the cell.
Mechanism of uptake
The receptor binding domain of the colicin binds to the outer membrane receptor CjrBC[1] on the target cell; it is a constitutively expressed protein parasitised by the colicin. The translocation domain then recruits proteins from the Ton system to translocate the protein across the membrane and into the cytoplasm.
