3pnd

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[[Image:3pnd.png|left|200px]]
 
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==FAD binding by ApbE protein from Salmonella enterica: a new class of FAD binding proteins==
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The line below this paragraph, containing "STRUCTURE_3pnd", creates the "Structure Box" on the page.
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<StructureSection load='3pnd' size='340' side='right'caption='[[3pnd]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pnd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PND FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3pnd| PDB=3pnd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pnd OCA], [https://pdbe.org/3pnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pnd RCSB], [https://www.ebi.ac.uk/pdbsum/3pnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pnd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APBE_SALTY APBE_SALTY] Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC, two subunits of the NQR complex.[UniProtKB:A5F5Y3]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The periplasmic protein ApbE was identified through the analysis of several mutants defective in thiamin biosynthesis and implicated as having a role in iron-sulfur cluster biosynthesis or repair. While mutations in apbE cause decreased activity of several iron-sulfur enzymes in vivo, the specific role of ApbE remains unknown. Members of the AbpE family include NosX and RnfF that have been implicated in oxidation-reduction associated with nitrous oxide and nitrogen metabolism respectively. In this work, we show that ApbE binds one FAD molecule per monomeric unit. The structure of ApbE in the presence of bound FAD reveals a new FAD binding motif. Protein variants that are non-functional in vivo were generated by random and targeted mutagenesis. Each variant was substituted in the environment of the FAD, and analyzed for FAD binding after reconstitution. The variant that altered a key tyrosine residue involved in FAD binding prevented reconstitution of the protein.
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===FAD binding by ApbE protein from Salmonella enterica: a new class of FAD binding proteins===
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FAD binding by ApbE protein from Salmonella enterica: a new class of FAD binding proteins.,Boyd JM, Endrizzi JA, Hamilton TL, Christopherson MR, Mulder DW, Downs DM, Peters JW J Bacteriol. 2010 Dec 10. PMID:21148731<ref>PMID:21148731</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pnd" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21148731 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21148731}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3pnd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PND OCA].
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Boyd JM]]
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==Reference==
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[[Category: Christopherson MR]]
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<ref group="xtra">PMID:21148731</ref><references group="xtra"/>
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[[Category: Downs DM]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Endrizzi JA]]
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[[Category: Boyd, J M.]]
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[[Category: Hamilton TL]]
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[[Category: Christopherson, M R.]]
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[[Category: Mulder DW]]
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[[Category: Downs, D M.]]
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[[Category: Peters JW]]
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[[Category: Endrizzi, J A.]]
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[[Category: Hamilton, T L.]]
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[[Category: Mulder, D W.]]
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[[Category: Peters, J W.]]
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Current revision

FAD binding by ApbE protein from Salmonella enterica: a new class of FAD binding proteins

PDB ID 3pnd

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