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3qnw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Caspase-6 in complex with Z-VAD-FMK inhibitor== | |
| + | <StructureSection load='3qnw' size='340' side='right'caption='[[3qnw]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qnw]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnw OCA], [https://pdbe.org/3qnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnw RCSB], [https://www.ebi.ac.uk/pdbsum/3qnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | ||
| - | + | ==See Also== | |
| - | + | *[[Caspase 3D structures|Caspase 3D structures]] | |
| - | + | *[[Caspase-6 and neurodegeneration|Caspase-6 and neurodegeneration]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Dominguez C]] | ||
| + | [[Category: Kiselyov A]] | ||
| + | [[Category: Lamers M]] | ||
| + | [[Category: Maillard M]] | ||
| + | [[Category: Mueller I]] | ||
| + | [[Category: Munoz I]] | ||
| + | [[Category: Park H]] | ||
| + | [[Category: Ritchie A]] | ||
Current revision
Caspase-6 in complex with Z-VAD-FMK inhibitor
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Categories: Homo sapiens | Large Structures | Synthetic construct | Dominguez C | Kiselyov A | Lamers M | Maillard M | Mueller I | Munoz I | Park H | Ritchie A
