2qcz

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(New page: 200px<br /><applet load="2qcz" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qcz, resolution 2.700&Aring;" /> '''Structure of N-term...)
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[[Image:2qcz.jpg|left|200px]]<br /><applet load="2qcz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qcz, resolution 2.700&Aring;" />
 
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'''Structure of N-terminal domain of E. Coli YaeT'''<br />
 
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==Overview==
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==Structure of N-terminal domain of E. Coli YaeT==
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Integral beta-barrel proteins are found in the outer membranes of, mitochondria, chloroplasts, and Gram-negative bacteria. The machine that, assembles these proteins contains an integral membrane protein, called, YaeT in Escherichia coli, which has one or more polypeptide, transport-associated (POTRA) domains. The crystal structure of a, periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a, model for how POTRA domains can bind different peptide sequences, as, required for a machine that handles numerous beta-barrel protein, precursors. Analysis of POTRA domain deletions shows which are essential, and provides a view of the spatial organization of this assembly machine.
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<StructureSection load='2qcz' size='340' side='right'caption='[[2qcz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qcz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QCZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qcz OCA], [https://pdbe.org/2qcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qcz RCSB], [https://www.ebi.ac.uk/pdbsum/2qcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qcz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAMA_ECOLI BAMA_ECOLI] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.<ref>PMID:15951436</ref> <ref>PMID:16102012</ref> <ref>PMID:16824102</ref> <ref>PMID:20378773</ref> <ref>PMID:21823654</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/2qcz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qcz ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2QCZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCZ OCA].
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*[[Bam complex 3D structures|Bam complex 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structure and function of an essential component of the outer membrane protein assembly machine., Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D, Science. 2007 Aug 17;317(5840):961-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17702946 17702946]
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__TOC__
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[[Category: Escherichia coli]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Escherichia coli K-12]]
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[[Category: Harrison, S.C.]]
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[[Category: Large Structures]]
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[[Category: Kahne, D.]]
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[[Category: Harrison SC]]
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[[Category: Kim, S.]]
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[[Category: Kahne D]]
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[[Category: Malinverni, J.C.]]
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[[Category: Kim S]]
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[[Category: Silhavy, T.J.]]
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[[Category: Malinverni JC]]
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[[Category: Sliz, P.]]
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[[Category: Silhavy TJ]]
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[[Category: membrane protein]]
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[[Category: Sliz P]]
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[[Category: potra domain]]
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[[Category: protein transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:52:38 2008''
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Current revision

Structure of N-terminal domain of E. Coli YaeT

PDB ID 2qcz

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