3odl

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[[Image:3odl.jpg|left|200px]]
 
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==Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247==
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The line below this paragraph, containing "STRUCTURE_3odl", creates the "Structure Box" on the page.
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<StructureSection load='3odl' size='340' side='right'caption='[[3odl]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3odl]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=YYA:2,4,5-TRIDEOXY-2-(METHYLAMINO)-4-[(2Z)-PENTA-2,4-DIEN-1-YL]-L-XYLONIC+ACID'>YYA</scene></td></tr>
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{{STRUCTURE_3odl| PDB=3odl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odl OCA], [https://pdbe.org/3odl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odl RCSB], [https://www.ebi.ac.uk/pdbsum/3odl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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E-ISA247 (voclosporin) is a cyclosporin A analogue that is in late-stage clinical development for the treatment of autoimmune diseases and the prevention of organ graft rejection. The X-ray crystal structures of E-ISA247 and its stereoisomer Z-ISA247 bound to cyclophilin A have been determined and their binding affinities were measured to be 15 and 61 nM, respectively, by fluorescence spectroscopy. The higher affinity of E-ISA247 can be explained by superior van der Waals contacts between its unique side chain and cyclophilin A. Comparison with the known ternary structure including calcineurin suggests that the higher immunosuppressive efficacy of E-ISA247 relative to cyclosporin A could be a consequence of structural changes in calcineurin induced by the modified E-ISA247 side chain.
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===Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247===
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Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).,Kuglstatter A, Mueller F, Kusznir E, Gsell B, Stihle M, Thoma R, Benz J, Aspeslet L, Freitag D, Hennig M Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):119-23. Epub 2011, Jan 15. PMID:21245533<ref>PMID:21245533</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3odl" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21245533}}, adds the Publication Abstract to the page
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21245533 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21245533}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3odl]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODL OCA].
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==Reference==
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<ref group="xtra">PMID:21245533</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Benz, J.]]
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[[Category: Tolypocladium inflatum]]
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[[Category: Hennig, M.]]
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[[Category: Benz J]]
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[[Category: Kuglstatter, A.]]
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[[Category: Hennig M]]
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[[Category: Stihle, M.]]
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[[Category: Kuglstatter A]]
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[[Category: Stihle M]]

Current revision

Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247

PDB ID 3odl

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