3q7b

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[[Image:3q7b.png|left|200px]]
 
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==Exonuclease domain of Lassa virus nucleoprotein==
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The line below this paragraph, containing "STRUCTURE_3q7b", creates the "Structure Box" on the page.
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<StructureSection load='3q7b' size='340' side='right'caption='[[3q7b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3q7b| PDB=3q7b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7b OCA], [https://pdbe.org/3q7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7b RCSB], [https://www.ebi.ac.uk/pdbsum/3q7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
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===Exonuclease domain of Lassa virus nucleoprotein===
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_21262835}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21262835 is the PubMed ID number.
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[[Category: Lassa virus Josiah]]
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[[Category: Hastie KM]]
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{{ABSTRACT_PUBMED_21262835}}
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[[Category: Kimberlin CR]]
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[[Category: MacRae IJ]]
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==About this Structure==
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[[Category: Saphire EO]]
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[[3q7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus Lassa virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7B OCA].
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[[Category: Zandonatti MA]]
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==Reference==
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<ref group="xtra">PMID:21262835</ref><references group="xtra"/>
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[[Category: Lassa virus]]
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[[Category: Hastie, K M.]]
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[[Category: Kimberlin, C R.]]
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[[Category: MacRae, I J.]]
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[[Category: Saphire, E O.]]
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[[Category: Zandonatti, M A.]]
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Current revision

Exonuclease domain of Lassa virus nucleoprotein

PDB ID 3q7b

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