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3qp9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase== |
| - | + | <StructureSection load='3qp9' size='340' side='right'caption='[[3qp9]], [[Resolution|resolution]] 1.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qp9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QP9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qp9 OCA], [https://pdbe.org/3qp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qp9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qp9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIKA2_STRVZ PIKA2_STRVZ] Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin/neomethymycin and pikromycin/narbomycin, respectively. Component of the pikromycin PKS which catalyzes the biosynthesis of both precursors 10-deoxymethynolide (12-membered ring macrolactone) and narbonolide (14-membered ring macrolactone). Chain elongation through PikAI, PikAII and PikAIII followed by thioesterase catalyzed termination results in the production of 10-deoxymethynolide, while continued elongation through PikAIV, followed by thioesterase (TE) catalyzed cyclization results in the biosynthesis of the narbonolide.<ref>PMID:10421766</ref> <ref>PMID:21570406</ref> <ref>PMID:19027305</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces venezuelae]] | ||
| + | [[Category: Keatinge-Clay AT]] | ||
| + | [[Category: Zheng J]] | ||
Current revision
The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase
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