This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3qr5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3qr5 is ON HOLD Authors: Lobo, P.A., Van Petegem, F Description: Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 d...) |
|||
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted== | |
| + | <StructureSection load='3qr5' size='340' side='right'caption='[[3qr5]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qr5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QR5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr5 OCA], [https://pdbe.org/3qr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qr5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Lobo PA]] | ||
| + | [[Category: Van Petegem F]] | ||
Current revision
Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted
| |||||||||||
