2qne

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(New page: 200px<br /><applet load="2qne" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qne, resolution 2.300&Aring;" /> '''Crystal structure o...)
Current revision (08:34, 30 October 2024) (edit) (undo)
 
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[[Image:2qne.jpg|left|200px]]<br /><applet load="2qne" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qne, resolution 2.300&Aring;" />
 
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'''Crystal structure of putative methyltransferase (ZP_00558420.1) from Desulfitobacterium hafniense Y51 at 2.30 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of putative methyltransferase (ZP_00558420.1) from Desulfitobacterium hafniense Y51 at 2.30 A resolution==
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2QNE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Desulfitobacterium_hafniense_y51 Desulfitobacterium hafniense y51] with <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNE OCA].
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<StructureSection load='2qne' size='340' side='right'caption='[[2qne]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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[[Category: Desulfitobacterium hafniense y51]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2qne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfitobacterium_hafniense_Y51 Desulfitobacterium hafniense Y51]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QNE FirstGlance]. <br>
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[[Category: JCSG, Joint.Center.for.Structural.Genomics.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: EDO]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: jcsg]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qne OCA], [https://pdbe.org/2qne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qne RCSB], [https://www.ebi.ac.uk/pdbsum/2qne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qne ProSAT], [https://www.topsan.org/Proteins/JCSG/2qne TOPSAN]</span></td></tr>
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[[Category: joint center for structural genomics]]
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</table>
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[[Category: protein structure initiative]]
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== Function ==
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[[Category: psi-2]]
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[https://www.uniprot.org/uniprot/MTGB_DESHY MTGB_DESHY] Methyltransferase able to methylate free cob(I)alamin in vitro, using glycine betaine as the methyl donor, yealding methylcobalamin (methylCbl) and dimethylglycine. In vivo, probably carries out the methylation of a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate (THF) for ultimate conversion to carbon dioxide; oxidation of the methyl group would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth of D.hafniense using glycine betaine. Cannot use quaternary amines such as carnitine and choline as substrates, nor tertiary amines such as dimethylglycine or trimethylamine.<ref>PMID:25313086</ref>
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[[Category: putative methyltransferase]]
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== Evolutionary Conservation ==
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[[Category: structural genomics]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: uncharacterized protein]]
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Check<jmol>
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[[Category: unknown function]]
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<jmolCheckbox>
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[[Category: zp_00558420.1]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/2qne_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:57:55 2008''
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qne ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Desulfitobacterium hafniense Y51]]
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[[Category: Large Structures]]

Current revision

Crystal structure of putative methyltransferase (ZP_00558420.1) from Desulfitobacterium hafniense Y51 at 2.30 A resolution

PDB ID 2qne

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