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3pd1

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[[Image:3pd1.jpg|left|200px]]
 
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==Caspase-3 K242A==
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The line below this paragraph, containing "STRUCTURE_3pd1", creates the "Structure Box" on the page.
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<StructureSection load='3pd1' size='340' side='right'caption='[[3pd1]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pd1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PD1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_3pd1| PDB=3pd1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd1 OCA], [https://pdbe.org/3pd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pd1 RCSB], [https://www.ebi.ac.uk/pdbsum/3pd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
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===Caspase-3 K242A===
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==See Also==
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*[[Caspase 3D structures|Caspase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3pd1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD1 OCA].
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__TOC__
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[[Category: Caspase-3]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Clark, A C.]]
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[[Category: Large Structures]]
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[[Category: Mattos, C.]]
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[[Category: Clark AC]]
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[[Category: Swartz, P.]]
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[[Category: Mattos C]]
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[[Category: Walters, J.]]
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[[Category: Swartz P]]
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[[Category: Walters J]]

Current revision

Caspase-3 K242A

PDB ID 3pd1

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