Interleukin-15/Sandbox
From Proteopedia
(New page: Interleukin-15 General Description Structural description (highlighting domains, folds and/or motifs) Structural insights into its function Links to evolutionarily related proteins Links ...) |
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| - | Interleukin-15 | + | (General Description) |
| + | Interleukin-15 (IL-15) is a 14-15kDa cytokine with similar biological functions to IL-2 (Kirman, 1998), eliciting such responses as differentiation and proliferation of lymphocytes, expression of cytolytic programs in lymphocytic killer cells, and chemoattraction of T cells (Chae, 1996). IL-15 has also been implicated in homeostatic proliferaton and deemed necessary for CD8+ T cell memory. In high enough concentrations, IL-15 has been implicated in chronic inflammatory diseases. | ||
| - | General Description | ||
| - | Structural description (highlighting domains, folds and/or motifs) | ||
| - | Structural insights into its function | ||
| - | Links to evolutionarily related proteins | ||
| - | Links to available structures | ||
| - | References & Notes | ||
| - | + | ==Structure & Function== | |
| - | == | + | ===Structure=== |
| + | (Structural Description) | ||
| + | (highlighting domains, folds and/or motifs) | ||
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| + | {{STRUCTURE_2psm| PDB=2psm | SIZE=300| SCENE= |right| CAPTION=Mouse interleukin-15 complex with interleukin-15 receptor α chain and benzamidine, [[2psm]] }} | ||
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| + | ==3D structures of interleukin== | ||
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| + | [[Interleukin]] | ||
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| + | [[Image:IL15-IL15Ra.png]] | ||
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| + | <!-- <Structure load='all.pdb' size='500' frame='true' align='right' {{Button Toggle AnimationOnPause}}<br> | ||
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| + | ===Function=== | ||
| + | (Structural insights into its function) | ||
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| + | ==Disease== | ||
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| + | ==Evolutionarily Related Proteins== | ||
| + | Proteins + (Links to evolutionarily related proteins) | ||
| + | example IL-2, IL-7 | ||
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| + | ==Solved Structures== | ||
| + | (Links to available structures) | ||
| + | 2PSM | ||
| + | 2Z3Q | ||
| + | 2Z3R | ||
| + | 2ERS | ||
| - | + | ==References & Notes== | |
Current revision
(General Description) Interleukin-15 (IL-15) is a 14-15kDa cytokine with similar biological functions to IL-2 (Kirman, 1998), eliciting such responses as differentiation and proliferation of lymphocytes, expression of cytolytic programs in lymphocytic killer cells, and chemoattraction of T cells (Chae, 1996). IL-15 has also been implicated in homeostatic proliferaton and deemed necessary for CD8+ T cell memory. In high enough concentrations, IL-15 has been implicated in chronic inflammatory diseases.
Structure & Function
Structure
(Structural Description) (highlighting domains, folds and/or motifs) This is a placeholder text to help you get started in placing a Jmol applet on your page. At any time, click "Show Preview" at the bottom of this page to see how it goes.
Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load and display another structure.
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| Mouse interleukin-15 complex with interleukin-15 receptor α chain and benzamidine, 2psm | |||||||||
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| Ligands: | |||||||||
| Gene: | Il15 (Mus musculus), Il15ra (Mus musculus) | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
3D structures of interleukin
