3qim

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[[Image:3qim.jpg|left|200px]]
 
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==Histidine 416 of the periplamsic binding protein NikA is essential for nickel uptake in Escherichia coli==
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The line below this paragraph, containing "STRUCTURE_3qim", creates the "Structure Box" on the page.
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<StructureSection load='3qim' size='340' side='right'caption='[[3qim]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qim]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3qim| PDB=3qim | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qim OCA], [https://pdbe.org/3qim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qim RCSB], [https://www.ebi.ac.uk/pdbsum/3qim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qim ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NIKA_ECOLI NIKA_ECOLI] Involved in a nickel transport system, probably represents the nickel binder.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Escherichia coli require nickel for the synthesis of [NiFe] hydrogenases under anaerobic growth conditions. Nickel import depends on the specific ABC-transporter NikABCDE encoded by the nik operon, which deletion causes the complete abolition of hydrogenase activity. We have previously postulated that the periplasmic binding protein NikA binds a natural metallophore containing three carboxylate functions that coordinate a Ni(II) ion, the fourth ligand being His416, the only direct metal-protein contact, completing a square-planar coordination for the metal. The crystal structure of the H416I mutant showed no electron density corresponding to a metal-chelator complex. In vivo experiments indicate that the mutation causes a significant decrease in nickel uptake and hydrogenase activity. These results confirm the essential role of His416 in nickel transport by NikA.
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===Histidine 416 of the periplamsic binding protein NikA is essential for nickel uptake in Escherichia coli===
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Histidine 416 of the periplasmic binding protein NikA is essential for nickel uptake in Escherichia coli.,Cavazza C, Martin L, Laffly E, Lebrette H, Cherrier MV, Zeppieri L, Richaud P, Carriere M, Fontecilla-Camps JC FEBS Lett. 2011 Feb 18;585(4):711-5. Epub 2011 Feb 1. PMID:21281641<ref>PMID:21281641</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qim" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21281641}}, adds the Publication Abstract to the page
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21281641 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21281641}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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[[3qim]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIM OCA].
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[[Category: Large Structures]]
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[[Category: Carriere M]]
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==Reference==
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[[Category: Cavazza C]]
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<ref group="xtra">PMID:21281641</ref><references group="xtra"/>
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[[Category: Cherrier MV]]
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[[Category: Escherichia coli]]
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[[Category: Fontecilla-Camps JC]]
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[[Category: Carriere, M.]]
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[[Category: Laffly E]]
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[[Category: Cavazza, C.]]
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[[Category: Lebrette H]]
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[[Category: Cherrier, M V.]]
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[[Category: Martin L]]
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[[Category: Fontecilla-Camps, J C.]]
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[[Category: Richaud P]]
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[[Category: Laffly, E.]]
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[[Category: Zeppieri L]]
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[[Category: Lebrette, H.]]
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[[Category: Martin, L.]]
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[[Category: Richaud, P.]]
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[[Category: Zeppieri, L.]]
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Current revision

Histidine 416 of the periplamsic binding protein NikA is essential for nickel uptake in Escherichia coli

PDB ID 3qim

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