3ml3

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[[Image:3ml3.jpg|left|200px]]
 
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==Crystal structure of the IcsA autochaperone region==
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The line below this paragraph, containing "STRUCTURE_3ml3", creates the "Structure Box" on the page.
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<StructureSection load='3ml3' size='340' side='right'caption='[[3ml3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ml3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ML3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ml3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ml3 OCA], [https://pdbe.org/3ml3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ml3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ml3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ml3 ProSAT]</span></td></tr>
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{{STRUCTURE_3ml3| PDB=3ml3 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the IcsA autochaperone region===
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[https://www.uniprot.org/uniprot/ICSA_SHIFL ICSA_SHIFL] Essential for bacterial spreading by eliciting polar deposition of filamentous actin (actin-based motility). Inside the host cell mediates nucleation and polymerization of actin molecules on the bacterial surface, which provides the propulsive force for intracellular movement and intercellular dissemination of the bacterium. During invasion of mammalian cells, triggers autophagy by binding to APG5L. Interaction with IcsB leads to escape from the autophagic host defense system. Also binds ATP and displays weak ATPase activity.<ref>PMID:7896693</ref> <ref>PMID:2542950</ref> <ref>PMID:1602963</ref> <ref>PMID:9582270</ref> <ref>PMID:15576571</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3ml3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML3 OCA].
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Diezmann, D.]]
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[[Category: Diezmann D]]
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[[Category: Kuhnel, K.]]
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[[Category: Kuhnel K]]

Current revision

Crystal structure of the IcsA autochaperone region

PDB ID 3ml3

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