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Telomerase 3D structures

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[[Image:Tert.png|left|200px|thumb|Structure of the catalytic subunit of telomerase, TERT, [[3du5]]]]
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==Telomerase 3D structures==
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{{STRUCTURE_3du5| PDB=3du5 | SIZE=300| SCENE=Telomerase/Cv/1 |right|CAPTION=Catalytic subunit of telomerase, TERT, [[3du5]] }}
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[Telomerase]] (TEL) adds DNA repeats to the tail end of telomeres. It carries its own RNA. The human TEL is composed of 2 [[Telomerase Reverse Transcriptase]] (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. The images at the left and at the right correspond to one representative Telomerase structure, ''i.e.'' crystal structure of catalytic subunit of telomerase, TERT, from ''Tribolium castaneum'' ([[3du5]]).
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*Telomerase reverse transcriptase
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**[[5c9h]] – hTERT + RNA - human<br />
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**[[4mnq]] – hTERT + MHC + b-2-microglobulin + T cell receptor<br />
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**[[5ugw]] – hTERT thumb domain<br />
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**[[7bg9]], [[7bgb]] – hTERT H/ACA RNP lobe – Cryo EM<br />
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**[[7qxa]] – hTERT + TPP1 + DNA – Cryo EM<br />
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**[[7qxb]], [[7qxs]], [[7trd]], [[7tre]], [[7trf]] – hTERT + TPP1 + POT1 + DNA – Cryo EM<br />
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**[[4lmo]] – TERT RNA binding domain - puffer<br />
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**[[4o26]] – TERT + telomerase TR – rice fish<br />
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**[[3du6]], [[3du5]] - rfbTERT catalytic subunit - red flour beetle<br />
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**[[5cqg]] - rfbTERT + inhibitor <br />
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**[[3kyl]], [[6e53]], [[6uso]], [[6usq]], [[6usp]] - rfbTERT + DNA<br />
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**[[7kqm]], [[7kqn]] - rfbTERT telomerase catalytic subunit + DNA + RNA<br />
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**[[6usr]] - rfbTERT + DNA + G2P<br />
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**[[2r4g]] - TtTERT telomerase catalytic subunit 1-1117 - ''Tetrahymena thermophila''<br />
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**[[2b2a]] - TtTERT telomerase catalytic subunit (mutant) <br />
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**[[7lma]], [[7lmb]] – TtTERT + telomerase-associated protein + RNA + DNA – Cryo EM<br />
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**[[7uy6]], [[7uy7]], [[8gap]] – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + RNA + DNA – Cryo EM<br />
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**[[7uy5]] – TtTERT catalytic subunit + P50 + P65 + TEB1 + TEB2 + TEB3 + telomerase-associated protein + RNA + DNA – Cryo EM<br />
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**[[6d6v]] – TtTERT + telomerase-associated protein + TEB2 + RNA + DNA – Cryo EM<br />
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**[[5c9h]] - TtTERT catalytic subunit + DNA<br />
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**[[5lgf]] - OgTERT N-terminal - ''Ogataea polymorpha'' - NMR<br />
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**[[5npt]] – OgTERT N-terminal <br />
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**[[6zd1]], [[6zd2]], [[6zd6]] - CaTERT – ''Candida albicans''<br />
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**[[6zdp]], [[6zdq]], [[6zdu]] - CaTERT + RNA <br />
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**[[7sbe]] – KlTERT RNA-binding domain 171-404 - ''Kluyveromyces lactis'' <br />
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{{TOC limit|limit=2}}
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*Telomerase RNA
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== 3D Structures of Telomerase ==
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**[[7trc]], [[7v99]], [[7v9a]] - hTERC in telomerase holoenzyme – Cryo EM<br />
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<br/>
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**[[1q75]], [[2k96]] – hTERC P2b hairpin (mutant) – human – NMR<br />
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[[3kyl]], [[3du5]], [[3du6]] – TERT+DNA – ''Tribolium castaneum''<br />
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**[[2k95]], [[1na2]] - hTERC P2b hairpin – NMR<br />
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[[2r4g]] – TtTERT RNA binding domain+RNA – ''Tetrahymena thermophila''<br />
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**[[2l3e]] - hTERC P2a P2b hairpin – NMR<br />
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[[2b2a]] – TtTERT (mutant)<br />
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**[[2qh2]] - hTERC CR7– NMR<br />
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[[2fey]] - TtTERC RNA P2b hairpin – NMR<br />
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**[[1ymo]] - hTERC stem loop IV – NMR<br />
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[[1q75]], [[2k96]] – hTERC RNA P2b hairpin (mutant) – human – NMR<br />
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**[[1z31]] - hTERC Pj6 hairpin – NMR<br />
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[[2k95]] - hTERC RNA P2b hairpin – NMR<br />
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**[[2kye]] - hTERC P6.1 hairpin – NMR<br />
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[[2qh2]] - hTERC RNA CR7– NMR<br />
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**[[2qh3]], [[2qh4]] - hTERC terminal hairpin loop – NMR<br />
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[[1na2]], [[1ymo]] - hTERC RNAstem loop IV– NMR<br />
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**[[5kqe]] - TERC P2b hairpin – ''Oryzias latipes'' - NMR<br />
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[[1z31]] - hTERC RNA Pj6 hairpin – NMR<br />
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**[[2fey]] - TtTERC P2b hairpin – NMR<br />
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**[[5kmz]] - TtTERC pseudoknot – NMR<br />
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**[[2m21]] - TtTERC stem loop IV – NMR<br />
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**[[2m22]] - TtTERC helix II – NMR<br />
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**[[2mhi]] - TERC CR4/5 – medaka - NMR<br />
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**[[2m8k]] - KlTERC pseudoknot - NMR<br />
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**[[8bh9]], [[8bh8]] - TERC + EST1 – ''Candida tropicalis''<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Telomerase 3D structures

Updated on 14-December-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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