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2dz7

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(New page: 200px<br /><applet load="2dz7" size="350" color="white" frame="true" align="right" spinBox="true" caption="2dz7, resolution 1.60&Aring;" /> '''DNA Octaplex Formati...)
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[[Image:2dz7.jpg|left|200px]]<br /><applet load="2dz7" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dz7, resolution 1.60&Aring;" />
 
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'''DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)'''<br />
 
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==Overview==
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==DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)==
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The crystal structure of the tetragonal form of d(gcGAAAgc) has been, revised and reasonably refined including the disordered residues. The two, DNA strands form a base-intercalated duplex, and the four duplexes are, assembled according to the crystallographic 222 symmetry to form an, octaplex. In the central region, the eight strands are associated by, I-motif of double A-quartets. Furthermore, eight hydrated-magnesium, cations link the four duplexes to support the octaplex formation. Based on, these structural features, a proposal that folding of d(GAAA)n, found in, the non-coding region of genomes, into an octaplex can induce slippage, during replication to facilitate length polymorphism is presented.
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<StructureSection load='2dz7' size='340' side='right'caption='[[2dz7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DZ7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dz7 OCA], [https://pdbe.org/2dz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dz7 RCSB], [https://www.ebi.ac.uk/pdbsum/2dz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dz7 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.
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==About this Structure==
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DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC).,Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599<ref>PMID:17062599</ref>
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2DZ7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem (Tokyo). 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17062599 17062599]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 2dz7" style="background-color:#fffaf0;"></div>
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[[Category: Kondo, J.]]
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== References ==
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[[Category: Mitomi, K.]]
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<references/>
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[[Category: Sato, Y.]]
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__TOC__
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[[Category: Sumani, T.]]
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</StructureSection>
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[[Category: Takenaka, A.]]
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[[Category: Large Structures]]
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[[Category: MG]]
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[[Category: Kondo J]]
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[[Category: a-quartet]]
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[[Category: Mitomi K]]
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[[Category: dna octaplex]]
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[[Category: Sato Y]]
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[[Category: non-coding dna]]
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[[Category: Sumani T]]
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[[Category: vntr]]
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[[Category: Takenaka A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:09:35 2008''
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Current revision

DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)

PDB ID 2dz7

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